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Development and evaluation of anti-inflammatory and anti-psoriatic potential of methanolic extract of Rubia cordifolia
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| Author:
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M.P.PAWAR , RUCHI CHOUBEY
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| Abstract:
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The main objective of this work was to test the anti-inflammatory and anti-psoriatic properties of a methanolic extract of Rubia cordifolia L. root in the creation of a hydrogel using several animal models. For hydrogel formulation, methanolic fraction (% w/w) was employed with various Carbopol 940 and sodium CMC combinations. The anti-inflammatory efficacy of the optimized hydrogel was tested in animals utilizing xylene-induced ear edema, croton oil-induced ear edema, and cotton pellet-induced granuloma models. Physical examination revealed that the produced hydrogels were brownish in color and had a homogenous and smooth look when applied. All other test criteria, including as pH, viscosity, spreadability, and consistency, were determined to be acceptable in the F3 hydrogel formulation. As a result, the optimal F3 formulation composition was found to be 1.5 g of Carbopol 940 and 1% sodium CMC. In xylene-induced ear edema in mice, the percent suppression of edema was found to be equivalent to the standard group of therapy (64.69 %). The results of this investigation show that the produced hydrogel of Rubia cordifolia L. has inhibitory effects on acute inflammation. The capacity of croton oil to promote neutrophil influx in mouse ear tissue was shown in this study. Administration with extract hydrogels, as well as Voltaren Emulgel, substantially decreased MPO and NO levels in mice ears (P<0.01). The presence of flavonoids in Rubia cordifolia L. may explain why the methanol extracts have a considerable anti-inflammatory effect.
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| Keyword:
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Rubia cordifolia L, hydrogel, anti-inflammatory, anti-psoriasis, methanolic extract
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2022.14.03.018
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| Download:
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