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Emerging Role Of Bioelectronic Medicines In Neuromodulation
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| Author:
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TANISHA DAS, SHIRIN SULTANA, SALIK ABDULLAH, PRIYANKA RAY
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| Abstract:
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Bioelectronic medicine (BEM) is a relatively recent strategy towards discovering novel neuromodulation therapeutics for diseases that have traditionally been addressed with pharmaceuticals. Bioelectronic therapies are conceived as programmable implants that use closed-loop (CL) activation of neurons that regulate autonomic processes to address damaged autonomic responses. Such technologies are intended to track markers of the intended activity and, if a malfunction is detected, send modulatory signals to the embedded system of nerves to restore the activity to standard. The peripheral nerve system (PNS) has a great deal of potential for therapeutic treatment and regaining bodily functioning. Autonomic nerves have recently gained much attention because they govern a wide range of processes engaged in organ homeostasis and chronic condition, and they look tractable to specific regulation of single nerve unit. Ongoing pre-clinical researches have eliminated current constraints by identifying the anatomical targets, discovering novel neural technology and devising effective signal processing algorithms. In this way, the most significant clinical outcomes have been achieved by various BEM methods and the challenges of neuro-modulatory treatments have shown promising results. The existing state of knowledge and future prospects for clinical uses of neural decoding and ANS stimulation are summarized below in this study. Additionally, how the advances got translated into clinical settings have been investigated from retrospective studies and presented herewith.
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| Keyword:
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Bioelectronic Medicine, Nanotechnology, Neuroscience, Vagus Nerve Stimulation, Neuromodulation.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2022.14.03.001
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| Download:
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