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The Anti-Tubercular Activity Assessment Of Extracts Of Medicinal Plants; Traditionally Used By Tribes Of India
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| Author:
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, DHARMENDRA KUMAR KUSHWAHA, RAJSHREE PANDEY, RAVISHANKAR KUSHWAHA
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| Abstract:
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Tuberculosis (TB) is a bacterial infection caused by Mycobacterium tuberculosis. It is classified as an acid-fast bacillus (AFB) because it retains stain after being treated with an acidic solution. Mycobacterium tuberculosis
is a gram-positive aerobic rod-shaped bacterium with a length of 1 to 4 micrometers. Mismanagement of anti-tuberculosis drugs approved for the treatment of TB increased drug-resistant Mycobacterium
tuberculosis.Consequently, treating multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis patientsis an enormous task for emerging and underdeveloped countries Therefore, medicinal plant-based drugs willbe one of the safest options for the treatment of multidrug resistant TB, Hence in
present study we haveevaluated the drug potential of Sida acuta Burm.f., Abelmoschus esculentus (Linn.) Moech, Adhatoda vasicaNees and Azadizachata indica A. Juss. These are well-known annual plants, distributed
throughout India, andtraditionally used by tribal communities in treatment for tuberculosis. The prepared powder from all theselected plants were used for the solvent based extraction using Soxhlet extractor with different solvents.The anti- tubercular potential assessment, all the extracts of water
and methanol were applied on the ATCCculture of Mycobacterium smegmatis (ATCC 607, Lot 114-26-4). In this study we have reported anti-tubercular potential in methonolic extract of leaves ofthe Adhatoda vasica Nees. This study provided thebaseline data for the drug development against Mycobacterium tuberculosis.
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| Keyword:
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Adhatoda vasica Nee, Tuberculosis, Mycobacterium smegmatis, methonolic extract, anti-tubercular potency.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.711
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| Download:
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