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Simultaneous spectrophotometric evaluation in pharmaceutical dosage type of trimethoprim and albendazole.
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| Author:
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KHUSHBOO GUPTA
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| Abstract:
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The article aims to develop a quick, sensitive, effective, precise and accurate spectrophotometric method for estimating tablet dosage forms on albendazole and Trimethoprim. Pure albendazole and Trimethoprim drug samples were dissolved in a methanol mixture with 1 N HCl (80:20). Two wavelengths chosen to form and resolve simultaneous equations were 248 nm for albendazole and 314 nm for Trimethoprim. Trimethoprim is an aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.Primarily it is used to treat urinary tract infection. Trimethoprim found with a combination of sulfamethoxazole has a synergistic effect due to the inhibitor effect during the mandatory sequence of enzymatic reactions in the bacteria occurring in more than one step. Albendazole is 5-propylthio-1H-benzimidazol-2-yl-carbamate chemically methyl[1]. The drug prevents the uptake of glucose in both larval and adult parasites, leading to reduced ATP development and subsequent parasite immobilisation.
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| Keyword:
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Simultaneous equation, Trimethoprim , Albendazole, Recovery
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.704
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| Download:
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Request For Article
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