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Design And Characterization Of Ethosomal Drug Delievry System Of Rilpivirine Hydrochloride
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| Author:
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RAJENDAR MEESA, K.B CHANDRASEKHAR, A.SRINIVAS
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| Abstract:
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Ethosomes are very effective since they enhance the penetration of drugs via skin to several times whose compound to the simple creams, elixirs and liposomal carriers. Hence, there is an absolute necessity to formulate ethosomes of the selected drugs, In the presant work ethosomal formulations of the selected drugs rilpivirine was prepared for obtaining the objective of improving skin permeability and bioavailability. The prepared formulations gave good percentage yield and size distribution. The maximum entrapment efficiency of Ethosomal vesicles as determined by ultracentrifugation was 75.3 % for Ethosomal formulation containing 20% ethanol (EF7) hence the best formulation of ethosomes of each respected drug were incorporated into carbopol based gel systems for controlled release. Results of entrapment efficiency also suggest that 2% phospholipids is optimalconcentration for entrapment efficiency and hence increased in concentration of phospholipids reduces the entrapment efficiency of vesicles. And the invitro studies proven that the formulations followed zero order release mechanisms. Compatability studies were performed for the materials selected and results are observed o be possitive. Stability studies indicated that the formulations were stable at low temperatures but can undergo rapid deformation at higher temperatures.
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| Keyword:
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Rilpivirine, Chitosan, Nanoparticles, HIV
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.529
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| Download:
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