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Validated Method Development For The Simultaneous Estimation Of Empagliflozin, Linagliptin, And Metformin In Marketed Formulation Using Uv Vis Spectrophotometer
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| Author:
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SHRIKRISHNA BAOKAR, RAJENDRA PATIL, ADITYA NATH PANDEY
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| Abstract:
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Insulin resistance and/or reduced production characterise type 2 diabetes mellitus (T2DM), resulting in higher blood sugar levels. It is rapidly spreading around the world and has recently become a top cause of death. The major goal of T2DM treatment is to keep blood sugar levels in check. Developing a single analytical approach for calculating individual medications from a multidrug combination is a difficult task. A new, simple, precise, accurate, reproducible, and efficient UV spectrophotometric method is developed and validated for the simultaneous estimation of ternary mixtures of Empagliflozin (EPG), Linagliptin (LNG), and Metformin (MET) in both bulk and combined in tablet dosage form for the treatment of Type 2 diabetes mellitus using the simultaneous equation method. In 0.1 N NaOH, the standard and sample solutions were made. MET, LNG, and EPG had maximum wavelengths of 232.0, 212.0, and 272.0nm, respectively. In the concentration ranges of 10-50g/ml for MET, 1-5g/ml for LNG, and 5-25g/ml for EPG, calibration curves are linear. According to ICH rules, the results of the simultaneous equation technique analysis were examined and validated for various parameters.
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| Keyword:
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Diabetes mellitus, Simultaneous equation method, Metformin, Linagliptin, Dapagliflozin
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.702
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| Download:
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