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Formulation and Evaluation of Ketoprofen Loaded Nanosponges for Topical Drug Delivery
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| Author:
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KHADKUTKAR VIJAYANANDA K, NAGOBA SHIVAPPA N, BAGWAN I.MOHDIN, SHAIKH NASHEER S
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| Abstract:
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Microsponges are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical Rheumatoid arthritis is a chronic, symmetrical, inflammatory autoimmune disease that initially affects small joints, progressing to larger joints, and eventually affecting the skin, eyes, heart, kidneys and lungs. Often, the bone and cartilage of joints are destroyed, and tendons and ligaments weaken. All this damage to the joints causes deformities and bone erosion that is very painful for a patient. The overall goals of first line treatment are to relieve pain and decrease inflammation. Medications considered as fast-acting drugs are non-steroidal anti-inflammatory drugs (NSAIDs) like ketoprofen. Ketoprofen is BCS class II drug (having poor solubility and high permeability) and it acts superficially so topical formulation can increase its efficacy. Hence, the objective of the present study was to formulate controlled release ketoprofen Nanosponges gel which alters the solubility and permeability of ketoprofen for increasing topical delivery. Ketoprofen was analysed for purity by UV analytical method. Nanosponges were prepared using various concentrations of Ethyl cellulose and PVA by emulsion solvent diffusion method. They were evaluated for percentage yield, percentage encapsulation efficiency, average particle size and polydispersity index, assay and in vitro permeation. F7 formulation was analysed by FTIR, drug content, in-vitro. FTIR results confirmed the absence of any drug polymer interaction. Optimized formulation was used to prepare gel formulation for topical application. Topical gels (G1, G2, and G3) were prepared by using different concentrations of carbapol and evaluated for pH, gel strength, assay, viscosity, spreadability and in vitro permeation. All formulations shows desirable pH and assay but G2 formulation was shows optimum viscosity, gel strength, Spreadability and highest in vitro permeation. Stability study for optimized formulation was done for three months and evaluated for all parameters. All parameters were well within range, so formulation was found to be stable. All these results confirm that nanosponges is ideal for increasing the solubility and permeability of poorly water soluble drug like ketoprofen and gel is best option for development of formulation.
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| Keyword:
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Ketoprofen, Nanosponges, topical gel, poor solubility, controlled release.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.03.527
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| Download:
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