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The Effect of Bergenia ligulata WALL in prediabetes: A randomized single-blind placebo-controlled study.
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| Author:
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ZARNIGAR , SABA KHAN
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| Abstract:
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Diabetes is preceded by a long, asymptomatic phase of intermediate hyperglycaemia referred to as “prediabetes “given the risk of progression to type 2 diabetes mellitus, heart disease, and stroke. Recognizing and intervening in the prediabetes phase is crucial. Lifestyle modification has been successfully tested for the prevention of diabetes in prediabetic subjects. But patients do not often comply with such regimens. The primary objective of the study was to examine the efficacy of the Bergenia Iigulata Wall in halting the progression to diabetes in pre-diabetic subjects. It was a single-blind randomized (1:1) placebo-controlled clinical trial conducted on 40 prediabetic subjects, randomly assigned 20 in the test and 20 in the control group. The test group was administered 4g powdered rhizome of Bergenia Iigulata Wall two times a day. The Control group was given an identical dosage of matched placebo. (Both groups were regularly counselled for adhering to a low glycaemic index diet chart and exercise plan). The duration of protocol therapy was 2 months. It was observed that both fasting blood glucose and OGTT showed a significant decline in the test group compared to the control group (p<0.001). This study concludes that the test drug Bergenia Iigulata Wall has hypoglycaemic potential and hence can be used prophylactically to delay/prevent diabetes in prediabetic subjects.
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| Keyword:
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Prediabetes; Bergenia Iigulata Wall; impaired fasting glucose; impaired glucose tolerance.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2022.14.01.024
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| Download:
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