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A Comprehensive Review on the Anti-cancer Profile of Thiazole Scaffold
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| Author:
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PRIYANKA , SALONI KAKKAR, ASHWANI KUMAR, MEENU BHAN, MEENAKSHI
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| Abstract:
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Azoles are also marked as containing nitrogen-nitrogen, nitrogen-oxygen and nitrogen-sulphur formed ring. Pyrazole, imidazole, triazole, tetrazole and pentazole are azole-containing nitrogen-nitrogen (N-N), while oxazole and isoxazole contain nitrogen-oxygen (N-O), and nitrogen-sulphur (N-S) containing azole are thiazole and isothiazole. over the last few decades, most pharmaceutical researchers have shown considerable interest in nitrogen and sulphur (N-S) comprising five membered heterocyclic moiety, thiazole (1,3-azole) for the production of new molecular varieties. Thiazole is a heterocyclic compound that contains sulphur and nitrogen atoms, and has major role in medicinal chemistry. It is an important scaffold present in many natural moieties (Vitamin B1-Thiamine). Thiazole is an aromatic compound based on the delocalization of a lone pair of electron from the sulphur atom, completing the 6p electron needed to satisfy the rule of Huckle’s. Biological profile of thiazole is very vast which includes anticancer, antimicrobial, antitubercular, anti-inflammatory, anti-HIV, antioxidant, antidiabetic, anticonvulsant, anti-Alzheimer’s potential etc. Some examples of thiazole compounds commonly used in rational medicine are: Sulfathiazole, nizatidine, meloxicam, abafungin, fanetinol, tizofurin, febuxostat and ritonavir. The thiazole ring & its derivatives have been modified at different positions to generate new molecules which have been further evaluated for its various therapeutic potentials. The aim of this review article is to report by the antimicrobial potential of heterocyclic thiazole scaffold in the last few years.
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| Keyword:
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Thiazole derivatives, Antimicrobial, Heterocyclic compound and Rational medicine.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.02.525
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