IJPR  articles are Indexed in SCOPUSClick Here     Impact Factor for Five Years is 0.13 (2013 - 2018).    

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence

IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Formulation Development and Evaluation of Sustained Release Matrix Tablet by Liquisolid Technique

Author: UPLOADED BY-ADMIN, IRSHAD AHMAD, CHETAN DEORE, MILIND UMEKAR, MINAL NEEL, SWEETY BANKAR
Abstract: It is suggested that Liquisolid technique has the potential to be optimized for the reduction of drug dissolution rate and here by production of sustained release systems. In the present study Losartan potassium was dispersed in Polysorbate 80 as the liquid vehicle. Then a binary mixture of carrier-coating materials (Eudragit RS or RL as the carrier and Silica as the coating material) was added to the liquid medication under the continuous mixing in a mortor. The final mixture was compressed using the manual tableting machine. The effect of drug concentration and loading factor on release profile of Losartan potassium from Liquisolid compact were investigated at two pH values (1.2 and 6.8). The release rate of Losartan potassium from Liquisolid compact was compared to the release of Losartan potassium from conventional tablets. Fourier transform infrared spectroscopy, X-Ray Crystallography and Differential Scanning Calorimetry were used to investigate the formation of any complex between drug and excipients or any crystallinity changes during the manufacturing process. Losartan potassium tablets prepared by Liquisolid technique showed greater retardation properties in comparison with conventional matrix tablets. This investigation provided evidence that Polysorbate 80 has important role in sustaining the release of drug from liquisolid matrices, and reduction of glass transition temperature of the polymer can be the reason for the release prolongation of liquisolid tablets. The kinetics studies revealed that most of the liquisolid formulations followed Korsmeyer- Peppas eq., which states that the release of drug might follow the mixed kinetics.
Keyword: Liquisolid Technique, Loading Factor, Sustained Release, Losartan potassium.
Download: Request For Article
 












ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free