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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Correlation between ultra-sonographic fetal soft markers and aneuploidy: prospective cross sectionalstudy

Author: BASSEM MOHAMED HASSANAIN, MAHA MOHAMED MOSAAD FARAG, YASMIN AHMED BASSIOUNY, AYMANMOHAMEDTAHER
Abstract: background: Over the past several decades, ultrasound screening in the second trimester to detect fetal malformations has advanced and improved dramatically; additionally, it is now feasible to detect even slight anatomical abnormalities. Some sonographic results are structural signals that have minimal or little pathogenic importance. Soft indicators are signals that are more typically observed in fetuses with congenital defects and are linked to chromosomal abnormalities. Method: This is an Observational prospective cross sectional study preformed on 100 pregnant women from 16-24 weeks of gestation with one sonographic fetal soft marker or more detected in their mid-trimester anomaly scan and followed up till delivery to evaluate the usefulness of each ultrasound soft marker, assess whether a specific soft marker should be looked for routinely on screening ultrasound. Results: Three cases of the studied group were associated with structural fetal anomalies (2 cases of them were associated with echogenic intracardiac foci , pyelectasis and Congenital heart disease and one case was associated with echogenic intracardiac focus , short long bones and omphalocele ), two cases of them were discovered post- natally to be Down syndrome. Conclusion: many soft markers will disappear or regress as gestation proceeds. The persistence or disappearance of a marker does not alter the risk of aneuploidy when it is isolated. But if combined soft markers are detected especially if associated with structural congenital anomaly, karyotyping should be offered for the newborn.
Keyword: ultra-sonographic fetal soft markers, aneuploidy.
DOI: https://doi.org/10.31838/ijpr/2022.14.01.008
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