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Antidiabetic Activity Of Selenicereus Undatus (Haw). Fruit Extract Against Alloxan Induced Diabetic Mice
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| Author:
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P.SONU, M.KISHORE, K.SRINIVAS, N.SANDHYA, S.JITHENDER KUMAR NAIK, B.NAGESH, S.RAJESWARI
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| Abstract:
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The disruption of glucose homeostasis caused by diabetes mellitus (the most common endocrine illness) can result in severe diabetic complications such as retinal disease, vascular disease, renal disease, and neuropathy, which can cause neurological problems as a result of the disruption in glucose use. Alloxan (ALN, 150 mg/kg body weight)-induced diabetic mice were treated with an ethanolic extract of Selenicereus undatus, a medicinal fruit that has long been utilized in traditional Chinese medicine. Diabetic mice were administered an ethanolic extract of the fruit Selenicereus undatus for 27 days, and their blood glucose levels reduced significantly in contrast to those of the control animals. Furthermore, diabetic mice had significantly higher levels of hepatic and renal marker activity than did control mice, indicating that they were suffering from diabetes. The treatment, which included Selenicereus undatus ethanolic fruit extract and metformin, was able to restore these measurements to levels that were close to normal.
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| Keyword:
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Selenicereus undatus, Alloxan monohydrate, Antidiabetic activity, Metformin, Hyperglycemic.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2022.14.01.005
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| Download:
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