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Experimental Investigation On Multiparticulate System For Antidepressant Drug
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| Author:
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MR.ABHISHEK PANDEY, GYANESHWAR SINGH, MR.KRISHNA KANT
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| Abstract:
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To combat neurodegenerative diseases, researchers throughout the globe are focusing on the use of plant extracts. Radiation protection against 1-diphenyl-1-picrylhydrazyl (DPPH) was 81% for both VSE and MLE. These two extracts have stronger ferric-reducing antioxidant power (FRAP) than the other extracts (33.57 0.20 and 26.76 0.30 mol Fe(II)/g dry weight, respectively). LC-QTOF/MS found MLE active compounds by liquid chromatography and mass spectrometry. As shown by the NBT test, MLE and VSE were found to have strong O2 scavenging (0.83/0.09 mg/ml and 0.98%/0.08 mg/ml, respectively). A DCFHDA experiment performed with 2, 7-dichlorodihydrofluorescein dictate (MLE) indicated that MLE was more effective at scavenging ROS, followed by PRE (0.71 +0.08 mg/ml, vs. 0.83 +0.08 mg/ml). A larger neuroprotective effect was found in PRE, while a higher cytotoxicity was found in MLE (viable cells 51% vs. 44%), and the IC50 was 1.92 0.04 mg/ml for MLE and 1.92 0.04 mg/ml for PRE, respectively. MLE, among the plants studied, has the greatest potential for neuroprotection.
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| Keyword:
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ROS; H2O2; oxidative stress; SHSY5Y neuroblastoma cell line, Moringa oleifera; superoxide anion;
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.02.436
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| Download:
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Request For Article
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