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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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In Vivo Antidiarrheal Activity of Bile Content of Catla Catla.

Author: NISRAT JAHAN, SABRINA AKTER
Abstract: Background: The present study aims to appraise the antidiarrheal activity of bile extract of Catla catla (family: Cucurbitaceae) in a mice model. Study Design & purpose: Bile extract of Catla catla in 50 mg/kg and 100 mg/kg B.W were administered to different Long Evan rat mice models to verify dose dependant antidiarrheal property. Methodology: In vivo antidiarrheal activity was performed by castor oil (0.5 ml /mice) induced method according to weight of wet stool. Bile extract of different doses were applied in six groups rat model in comparison to standard Loperamide (10mg/kg B.W). As negative control castor oil in saline solution was used. Results: Inhibition of gastric motility was confirmed by 50 mg/kg and 100 mg/kg B.W bile of fishin the value of 59.8% (***P<0.001) & 72.8% (***P<0.001) respectively whereas 83.4% (***P<0.001) fecal frequency was recorded for Loperamide. Conclusion: The upshot results of the present study confirmed antidiarrheal of the bile content of C. catla that could be a possible well expected speculation as a potent antidiarrheal agent.
Keyword: C. catla, Cyprinidae, antidiarrheal activity, pharmacological activity.
DOI: https://doi.org/10.31838/ijpr/2022.14.01.002
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