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In Vivo Antidiarrheal Activity of Bile Content of Catla Catla.
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| Author:
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NISRAT JAHAN, SABRINA AKTER
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| Abstract:
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Background: The present study aims to appraise the antidiarrheal activity of bile extract of Catla catla (family: Cucurbitaceae) in a mice model.
Study Design & purpose: Bile extract of Catla catla in 50 mg/kg and 100 mg/kg B.W were administered to different Long Evan rat mice models to verify dose dependant antidiarrheal property.
Methodology: In vivo antidiarrheal activity was performed by castor oil (0.5 ml /mice) induced method according to weight of wet stool. Bile extract of different doses were applied in six groups rat model in comparison to standard Loperamide (10mg/kg B.W). As negative control castor oil in saline solution was used.
Results: Inhibition of gastric motility was confirmed by 50 mg/kg and 100 mg/kg B.W bile of fishin the value of 59.8% (***P<0.001) & 72.8% (***P<0.001) respectively whereas 83.4% (***P<0.001) fecal frequency was recorded for Loperamide.
Conclusion: The upshot results of the present study confirmed antidiarrheal of the bile content of C. catla that could be a possible well expected speculation as a potent antidiarrheal agent.
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| Keyword:
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C. catla, Cyprinidae, antidiarrheal activity, pharmacological activity.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2022.14.01.002
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| Download:
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