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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Effect of ethanolic extract of Allium sativum and Terminalia belerica on clonidine and clonidine and haloperidol-induced catalepsy in mice

Author: UPLOADED BY-ADMIN, BHAVIN A. VYAS, RUCHI B. VYAS
Abstract: Ethanolic extracts of A. sativum and T. belerica, recommended in Ayurvedic system of medicine for use in asthma, were evaluated for mast cell stabilizing and anti-cataleptic activity to find possible mode of action of these plants in management of asthma. Clonidine-induced mast cell degranulation was used to assess mast cell stabilizing activity of the extracts, while effect of extracts on catalepsy was evaluated by clonidine and haloperidol-induced catalepsy. In clonidineinduced mast cell degranulation, mice pretreated with disodium cromoglycate, A. sativum or T. belerica showed significant reduction in degranulation as compared to control group. Single dose of A. sativum potentiated clonidine-induced catalepsy but on repeated doses (once in a day for 4 days) inhibited catalepsy, while T. belerica inhibited catalepsy even on single dose treatment. Both plants showed no effect on haloperidol-induced catalepsy. The results of present study suggest usefulness of A. sativum and T. belerica in management of asthma probably due to their mast cell stabilizing effect.
Keyword: Catalepsy, mast cell stabilizer, clonidine, haloperidol, anti-asthmatic
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0.12
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