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The Association of Hospital Acquired Infections with Mortality Rate in Post-Cardiac Surgery Patients
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| Author:
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NIK NAJIBAH NIK-ABDUL-RAHMAN, KARMELIA CHAN SOOK-CHING, EILEEN YII SIE-EE, FARIZAN ABDUL-GHAFFAR
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| Abstract:
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Background: Hospital-acquired infections (HAIs) have become one of the important complications and increased mortality in post-cardiac surgery. Limited studies had been done to evaluate clinically the relationship between HAIs following broad range of cardiac surgical procedures. This study aimed to determine the association of HAIs with mortality rate in post-cardiac surgery patients and to identify the predictors that influence the outcome of mortality.
Results: There were 119 patients of a tertiary care facility with a clinical indication for cardiac surgery from June 2017 to December 2018 were included in the study (73.9% male, mean age 55.7±12.9 years). Out of these patients, 55.5% developed HAIs. The mortality rate was higher in patients who developed HAIs compared to non-HAIs (51.5% vs. 32.1% respectively). In the multivariate analysis, = 3 comorbidities (adjusted OR 3.5; 95% CI 1.4-9.0; p = 0.009) and patient treated with second generation cephalosporins as antibiotic prophylaxis (vs first generation cephalosporins (adjusted OR 3.1; 95% CI 1.12-8.1; p = 0.025) were significantly associated with increased risk of mortality.
Conclusion: This study found that HAIs was not associated with increased mortality rate in post-cardiac surgery patients. The number of comorbidities and type of antibiotic prophylaxis were significantly associated with mortality post-cardiac surgery. Thus, it is important to evaluate adequacy of practice guidelines to reduce HAI especially in increased risk patients in order to reduce the rate of mortality.
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| Keyword:
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hospital-acquired infections, cardiac surgery, mortality
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.04.005
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| Download:
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