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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Biological source and virtual screening of phytochemicals present in important ayurvedic plant, Sesbania sesban targeting spike proteins of SARS CoV2 for treatment of COVID 19

Author: SAPTARSHI SAMAJDAR
Abstract: SARS-CoV-2 is a novel coronavirus strain that first surfaced in China in December 2019. New antiviral medications have made significant progress in recent years, and natural products are crucial sources of prospective and new antiviral treatments. Molecular docking methods were used to evaluate various biologically active chemicals contained in an important ayurvedic plant, Sesbania sesban, a perennial legume tree, as possible COVID-19 inhibitors. Two main ayurvedic compositions obtained from the plant are Ratnagiri Rasa and Mahapaisachikaghritam. PyRx software was used to conduct the docking study, which included around 19 compounds tested on two targets. These chemicals could be used to stop COVID-19 from infecting people. The findings show that this screening technique is effective, and that it can lead to quick medication discovery in response to novel infectious diseases. Many chemicals identified from medicinal plants, such as Oleanic acid (-12.2 and – 9.3 kcal/mol), Malonic acid (– 7.6 and 7.5 kcal/mol), and Leucocyanidine (– 7.3 and -7.1 kcal/mol), are important sources for novel antiviral medicines targeting COVID-19, according to the findings.
Keyword: COVID-19, Anti-viral, Ayurvedic plant, Sesbania sesban, Docking study •
DOI: https://doi.org/10.31838/ijpr/2021.13.04.006
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