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Formulation And Development Of Quetiapine Mouth Dissolving Films Using Doe Approach
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| Author:
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MEGHA AGRAWAL, SHAH DHIREN P
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| Abstract:
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The objective of the current work is to formulate and evaluate the mouth dissolving film of Quetiapine. It is ideally suitable for the treatment of emesis. Mouth dissolving dosage forms are gaining popularity in recent times, as these dosage forms requires no water for administration. develop mouth dissolving films (MDF) of Quetiapine for the treatment of hypertension, with fast disintegration, optimum morphological properties, and mechanical strength. HPMC E5, PEG- 400 were used as the hydrophilic film-forming polymeric bases. Films were prepared by solvent casting technique. Parameters like in-vitro disintegration time, tensile strength, content uniformity, folding endurance, swelling index, and in-vitro drug release were evaluated. 3² factorial design was used to optimize the amounts of the polymer and the plasticizer. In-vitro dissolution studies showed that 96.37±1.21 of Quetiapine was released within 5 min with an average disintegration time of 25 sec. FTIR spectrophotometry were used to identify drug-excipient interactions.
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| Keyword:
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Quetiapine, Mouth Dissolving Films (MDF), 3² factorial design, In-vitro dissolution studies
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.690
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| Download:
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