*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
The Effect of Green Tea Leaves (Camellia Sinensis) Ethanol Extract Administration on The Ephitelium Thickness of Seminiferous Tubules and Number of Sertoli Cell in Mice (Mus Musculus) Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD)

Author: AKHMAD AFIFUDIN AL-ANSHORI, LILIK MASLACHAH, EPY MUHAMMAD LUQMAN, RAHMI SUGIHARTUTI, ARIMBI, WIDJIATI
Abstract: This study aimed to determine the effect of green tea leaves on the Sertoli cells count and the seminiferous tubule epithelial thickness. This study used twenty-five adult male mice (Mus Musculus) BALB / C strains weighing 25-30 grams. The mice were divided into five groups (5 mice each group) depends on the combination of TCDD and green tea leaves ethanol extract which was designed as follows: (K-) 0 mg/Kg BW/day and 0 µg/Kg BW, (K+) 1.2 mg/Kg BW/day and 7 µg/Kg BW, (P1) 1 mg/Kg BW/day and 7 µg/Kg BW, (P2) 2 mg/Kg BW/day and 7 µg/Kg BW, and (P3) 4 mg/Kg BW/day and 7 µg/Kg BW. TCDD is injected as a single dose and green tea leaves ethanol extract administered orally for 53 days. Testicular histology slide was made with HE staining, to count the Sertoli cell and measure the seminiferous tubule epithelial thickness. Data were analyzed with One Way ANOVA and followed by Duncan's test. The results of this study showed a significant difference (p <0.05) between the treatment groups. This study concludes that the administration of green tea leaves ethanol extract 4 mg/Kg BW/day (P3) is the most effective group to maintain the Sertoli cells count (28.76 ± 2.24; p<0,05) and epithelial thickness (22.11 ± 0.49; p<0.05) because green tea extract has antioxidant effect to repair the male reproductive organ damage due to oxidative stress.
Keyword: Green tea, mice (Mus musculus), Sertoli cell, epithelial thickness of seminiferous tubules, TCDD
DOI: https://doi.org/10.31838/ijpr/2022.14.01.001
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free