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Design, Development And Characterization Of Nano-Emulsion Based Nicardipine Hydrochloride Gel 20mg
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| Author:
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G.GOPI, B.KUMAR, K.B.CHANDRA SEKHAR
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| Abstract:
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Nicardipine belongs to BCS class-II drug having low solubility and orally bioavailability of about 10-40%. The objective of the present study is to develop a nanoemulsions based gel Nicardipine formulation to increase the solubility and diffusion to increase the bioavailability while reducing variability in systemic exposure. The obtained ratio of 3%:1:2 of Drug, Light liquid paraffin. . Ternary phase diagrams were constructed by varying Tween 80: PEG-400 ratios as 1:1, 1:2, and 2:1. The ternary phase system of Tween 80: PEG-400, (1:1, 2:1) that exhibited maximum area for nanoemulsions formation and inviro diffusion for the optimization of nanoemulsion batch. The Nano-emulsion was prepared into gel by 1.5% using chitosan gelling agent with 2% Eucalyptus oil shown homogeneity of drug. The Nicardipine Hydrochloride gel was shown good stability in the studies. The bioavailability studies of Nicardipine nanoemulsion based gel was shown Cmax158.46 ng/ml, T max at 6 Hr, AUC(0-8) at 464.9 ng.min/ml and t1/2 at 6.15 hr. AUC and maximum plasma concentration of Nicardipine nanoemulsion gel is higher than pure nicardipine drug it indicates Nicardipine nanoemulsion based gel produce more bioavailability than nicardipine hydrochloride. Thus, the prepared Nicardipine nanoemulsion gel proved to be a potential technology for enhancing the transfer of poorly water soluble lipophilic compounds to the aqueous phase, thus enhancing the bioavailability.
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| Keyword:
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Nicardipine, Tween-80, Chitosan, Eucalyptus oil.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.688
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| Download:
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