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Formulation And Evalution of Cefixime by Liposomal Technique
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| Author:
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AZRA UNNISA, DR.A.MADHUKAR
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| Abstract:
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Cefixime is widely used as prescription and no-prescription medicine. The aim of study, developing and
optimizing liposomal formulation of cefixime is to improve its anti-cancer activity, to prepare cefixime liposome
using thin lipid film hydration using Rota evaporator which is considered a cost effective and simple method of
manufacturing. Cefixime has moderate anti-cancer activity as DNA binding agent an antibiotic drug (3rd
generation cephalosporin drug), so it is formulate as liposome formulation for effective targeting action with
minimal side effects. Liposomes are micro particulate lipoid vesicles which are under investigation as drug carriers
for improving the delivery of therapeutic agents. New development in liposome technology, liposomes based
drug formulations are currently in clinical trial, and recently some of them have been approved for clinical use.
In this research liposome formulation of cefixime was Prepared and evaluated for vesicle shape (SEM), drug
entrapment efficiency. From all the characterizations the entrapment of the drug was found as 95.03%.
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| Keyword:
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Liposome’s, cefixime, percentage drug entrapped
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.682
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| Download:
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