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Design of Experiment Approach in Development of Hydrophilic Matrix Tablet of Venlafaxine HCl: In vitro and In vivo studies
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| Author:
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MARIA SAIFEE, V.U.RAO, S.D.BARHATE
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| Abstract:
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The objective of the study was to develop hydrophilic matrix drug delivery system of venlafaxine HCl (Ven HCl) for once a day administration. The formulation was optimized using Design of Experiment, 33 full factorial designs were used to optimize independent variables i.e. concentrations of hydroxypropyl methylcellulose (HPMC) K 4M, K15M, and K100M. Formulations were statistically analysed using design Expert software and design of space was determined using contour and surface response plot. The optimized formulation was prepared within the design space and evaluated for various in vitro and in vivo parameters. The in vivo studies of optimized formulation was done against the pure solution of Ven HCl in rabbits and parameters like Cmax, Tmax and AUC was compared. Optimized formulation showed lower Cmax (p<0.0001) and the time (Tmax 6 h) required to reach peak plasma concentration (Cmax) was also longer as compared to the immediate oral solution.
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| Keyword:
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Hydroxypropyl methylcellulose, design of experiment, targeted dissolution profile, matrix drug delivery system, venlafaxine HCl.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.678
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| Download:
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