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Development of floating mini tablets loaded with chitosan Lisinopril microparticles
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| Author:
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, CHATLAPELLI KISHORE, K.BHASKAR REDDY, S.V.SATYANARAYANA
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| Abstract:
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Lisinopril is an angiotensin converting enzyme inhibitor, usually prescribed in treatment of hypertension and require long term use for its therapeutic benefit. Once a daily Lisinopril oral formulation would be significant in reducing the fluctuations in blood concentration and increasing patient compliance. Chitosan microparticles were developed with aim to improve the permeability and it was further incorporated in the gastroretentive floating mini tablets. Chitosan microparticles were systemically developed by applying Plackett Burman design for screening different formulation factors. Total 11 factors were screened at two levels considering % entrapment efficiency as the response. Chitosan concentration, TPP concentration and speed of stirring were the significant factors out of total 11 factors screened. These 3 factors were further optimized with 32 full factorial design. Optimized microparticles were evaluated for %entrapment efficiency, zeta potential, particle size, and dug release. Maximum %entrapment efficiency was found to be 81%, Particle size of the optimized batch was 364.9nm and PDI of 0.407 indicating polydisperse nature of particle. Zeta potential was 9.16 indicating mucoadhesive behavior of developed microparticles. Surface morphology was studied with SEM confirming smooth external surface of irregular v shape microparticle. Optimized dug microparticles were further loaded in floating minitablets. Developed mini tablets were evaluated for average weight, % friability, assay, content uniformity, dissolution, total floating time and floating lag time.
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| Keyword:
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Gastroretentive drug delivery, lisinopril,minitablets
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.832
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| Download:
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