|
Solubility Enhancement by Self-Micro Emulsifying Drug Delivery System
|
|
| Author:
|
MAHESH BIRADAR, PARUL MEHTA
|
| Abstract:
|
Poor water solubility is a major challenge for orally administered drugs; thus, different strategies are utilized to enhance their solubility and oral bioavailability. A greater attention has been given in recent times to SMEDDS. In order to improve the solubility and oral bioavailability of drugs that are poorly water soluble, SMEDDS is a promising strategy in which pre-dissolving the drug is capsuled to formulate physically stable formulations. SMEDDS is formulated by a self-emulsification mechanism which occurs due to the change in entropy. SMEDDS have advantages such as pre-dissolving formulation overcomes the dissolution as a rate limiting step, improved oral bioavailability, ease of manufacture, avoiding or preventing GIT degradation, and no effect on the process of lipid digestion. Formulation consists of active pharmaceutical ingredients and excipients such as oil/lipid, surfactant, co-surfactant, co-solvents etc. SMEDDS Formulation design involves screening of excipient by solubility studies and emulsification efficiency studies; Pseudo-ternary Phase Diagram construction & its Preparation. Characterizations of SMEDDS involve Visual Evaluation, Droplet Size Analysis, Zeta Potential Measurement, Percentage Transmittance, and Refractive Index.
|
| Keyword:
|
Poor water solubility, micro emulsion, self-emulsification, pre-dissolving, and oral bioavailability.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.03.221
|
| Download:
|
Request For Article
|
|
|