|
|
|
|
|
|
Article Detail
|
|
Label
|
|
|
Label
|
|
|
|
An observational study on prescribing pattern and effect of medication adherence on clinical outcomes in type 2 diabetes
|
|
| Author:
|
SOURABH KOSEY, SAURABH SHARMA
|
| Abstract:
|
Objective: Medication adherence is impacted by regimen complexity of the Diabetes mellitus. This observational study aimed to investigate the prescribing pattern and effect of medication adherence on clinical outcomes in type 2 diabetes.
Research design and methods: This was an observational study was approved by the Institutional Ethical Committee (196/IEC/2011) and it was undertaken in Guru Gobind Singh Medical College, Faridkot, Shanti Devi Thapar Hospital, Moga, Garg Hospital, Zira, Metro Hospital, Bagghapurana, and Fortis Hospital, Ludhiana, India. A total number of 1150 patients were screened out of which 1022 in baseline group were allocated. On follow-up 970 patients completed the study. A total of patients with diabetic aged between 21 and 65 years, either sex, with co-morbidities, on oral hypoglycemic agents (either metformin or glibenclamide or its combination), having disease 10 years with HbA1c level >7% were included in the study. Adherence rate was calculated for each study medication at each follow-up visit; participants were classified as =80% or <80% adherence.
Result: The most prevalent co-morbities were HTn, CVD, GID, hyperthyroidism, Retinopathy neuropathy and nephropathy. Monotherapies (369 cases) have been prescribed more in comparison to the combination therapies (311 cases). Clinical outcomes observed after pharmacist’s intervention was highest in the case of PPBG (210±8.8 mg/dl) from the base line (342.9±8.3 mg/dl) in 6 months. Other parameters TC, TG, LDL, HDL, VLDL, Creatinine, Uric acid, and BUN have also shown significant improvement after pharmacists’ intervention. Medication regimen, Height (Ht.), Weight (Wt.), Body mass index (BMI), Blood Pressure (BP), Glycated Hemoglobin (HbA1c), and lipid profile showed more than 80% adherence when studied in total of 970 patients.
Conclusions: Adherence was higher with the medication regimen. Greater adherence to the simpler regimen amplified the treatment effect on HbA1c, BP, lipid profile, and eye, yet statistically significant greater benefits were noted even when adjusted for adherence.
Trial registration number: NCT01966978
|
| Keyword:
|
Diabetes; observational; T2DM; prescribing pattern; medication adherence
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2020.12.04.676
|
| Download:
|
Request For Article
|
|
|
|
|
|
|
|
|
|
|