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Antiurolithiatic Activity Of Lantana Camarahydroalcoholic Flower Extract By Nucleation And Aggregation Assay
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| Author:
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KEERTHANA ARRA, PASUPULA RAJESHWARI, UMASHANKAR KULANDAIVELU, CHAKRAVARTHI
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| Abstract:
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Renal calculus also referred as kidney stones, are a result of aggregation of minerals and salts in the kidney into a solid crystal structures resembling pebbles with varying size ranges in urinary tract or kidney. They occur when concentration of certain minerals increases in the urine. The entire process of stone formation in any part of urinary tract is called as Urolithiasis which can be described by several stages like super-saturation, nucleation, growth, aggregation and retention within the kidneys. Lantana Camara is, is one of the widely used traditional herb in therapeutic management of varied diseased conditions that also includes urolithiasis. Pashanabheda is an antiurolithiatic prescribed as an Ayurvedic medicine. In the present study, flowers of Lantana Camara were selected for screening in vitro antiurolithiatic potentials, as literature supports that flowers have highest quantity of natural constituents when compared with the other parts of the plant.Hydroalcoholic (80-20%) extract of Lantana Camara flowers was prepared and phytochemical investigation was done. Finally, invitro antiurolithiatic activity was screened by nucleation and aggregation assay.In the aggregation assay gradually decrease in the CaOx crystal nucleation as well as growth was observed by light microscopy.The findings of the nucleation assay indicate that phytoconstituents resulted in inhibition of CaOx crystallization in solution whose concentration and size decreased with increase in concentration of the phytoconstituents in range of 100,200,300,400 and 500 µg/ml. The hydroalcoholic flower extract of L.camarahas shown antiurolithiatic effect by signi?cantly reducing the CaOx crystal growth.
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| Keyword:
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Lantana Camara, antiurolithiatic activity, Hydroalcoholic extract, aggregation assay
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.828
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| Download:
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