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Article Detail
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Assertion of Toxicological Profile and Laxative Nature of Yash Churna
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| Author:
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KAUSIK BHAR, SUMANTA MONDAL, SUVENDU KUMAR SAHOO, GANAPATY SERU
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| Abstract:
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For thousands of years, Ayurvedic medicines have been utilised in healthcare profession and have made significant contributions to preserving and improving human health. Despite the fact that its medicines have been used for millennia and are known to be non-toxic and assumed to be non-toxic, there is no objective verifiable data to back up the numerous claims. The current investigation sheds light on the acute and sub-acute (15-day) toxicity of the aqueous extract of Yash churna (AEYC), as well as the extract's laxative efficacy. Acute toxicity tests were conducted using limit doses of 1000, 1500, and 2000 mg/kg body weight. Observations were made and recorded for 24 hours, then once a day for the next 14 days. As a result, the AEYC was given orally for 15 days at 400 mg/kg b.wt., to evaluate sub-acute toxicity. Haematological analysis and biochemical markers were assessed at the conclusion of each trial. The animals' critical organs were examined histopathologically for gross results and compared to controls. In addition, the impact of Yash churna aqueous extract (200 and 400 mg/kg, b.wt., p.o.) on gastrointestinal motility and laxative efficacy in loperamide-induced constipation was investigated. No mortality or any major signs of morbidity was recorded for acute toxicity except for the limit dose (2000 mg/kg, body weight) which produced a slight short-term sedative and mild laxative effects. In sub-acute toxicity, the extract at the dose 400 mg/kg, body weight., was administered orally for 15 days. Important parameters such as general behaviour, organ weight, urinalysis, haematological and biochemical profile, organ macroscopy and microscopy were conducted. Organ sample of liver, kidney and pancreas, were taken from both male and female rats, whereas the sample of testis and ovary was taken from male and female rats respectively for organ necropsy and histopathological studies. In sub-acute toxicity, no major alteration was observed in the evaluated parameters. In-addition, the aqueous extract of Yash churna applied orally (200 and 400 mg/kg; p.o.), produced significant laxative activity on loperamide induced constipation in dose dependant manner. The effect of the extract at 200 and 400 mg/kg (p.o.) was similar to that of reference drug sodium picosulfate (5 mg/kg, p.o.). Furthermore, at same doses of the extract produced a significant increase (p < 0.01) of intestinal transit in comparison with castor oil. Yash churna might be a potential functional Ayurvedic churna or laxative agent for the treatment of spastic constipation, with reduced toxicity at the dosage levels evaluated.
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| Keyword:
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Acute toxicity, Gastrointestinal motility, Laxative, Sub-acute toxicity, Yash Churna.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.202
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| Download:
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Request For Article
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