|
One-Pot Synthesis, Characterization And Invitro Antimicrobial Activity Of Novel Pyrimidine Derivatives
|
|
| Author:
|
A. RAMAKOTI REDDY, T. RAMAMOHAN REDDY
|
| Abstract:
|
Search for effective novel antimicrobial agents is a never-ending task. Current research work comprised of finding a novel series of various substituted pyrimidine derivatives. The synthetic scheme involves single-step, one -pot synthesis involving the condensation of highly activated amide starting materials with weakly nucleophilic alkyl and aryl nitriles to directly provide the corresponding pyrimidine derivatives employing trifluoromethanesulfonic anhydride catalyst. All the synthesized compounds were characterized by IR, 1HNMR and MASS spectral methods and screened for antimicrobial activity against four bacterial strains B.subtilis, S.aureus, E.coli, P. aeruginosa and two fungal strains A.niger and C.albicans. All the compounds displayed decent antimicrobial profile when compared with the standard drugs neomycin and nystatin. Among the synthesized compounds (3a1-3a5&3b1-3b5) tested, compounds 3a1, 3a3, 3a4, 3b3 and 3b4 have demonstrated excellent antimicrobial activity against selected strains of bacteria and fungi.
|
| Keyword:
|
Pyrimidines, Anti-bacterial activity, Antifungal activity, One-pot synthesis, Agar disk diffusion.
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.03.195
|
| Download:
|
Request For Article
|
|
|