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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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In Vitro Dissolution Enhancement of Ziprasidone by Solid Dispersion Technique

Author: UPLOADED BY-ADMIN, JANARDHAN JUTURI, SRINIVAS REDDY DEVIREDDY, VASAVI PACHIKA
Abstract: The solubility behavior of drug is one of most challenging aspects in the formulation development. Enhanced dissolution of drugs can help in improved bioavailability of the drug product. The objective of this work is to improve the solubility and dissolution rate of poorly water soluble drug ziprasidone (antipsychotic agent) by solid dispersion method. Solid dispersions of ziprasidone were prepared by fusion method using different carriers (Vit E TPGS, Gelucire 44/14 and 50/13) in different ratios (1:0.1, 1: 0.2 and 1:0.3; Drug:Carrier) were used. The solubility was increased with increase in respective carrier concentration. All solid dispersions have shown high dissolution rates as compared to pure ziprasidone. Ziprasidone with Gelucire 44/14 at 1:0.3 ratio has significant improvement (four fold) in dissolution after 20 min than other carriers. In ageing studies there was no significant difference was observed. FT-IR spectroscopy, differential scanning calorimetry studies revealed that there was no significant interaction was occured between drug & carrier. From XRD studies the conversion of crystalline form to amorphous form was observed.
Keyword: Ziprasidone, Vit E TPGS, Gelucire 44/14, 50/13, Fusion Method, Solid Dispersion.
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