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In Vitro Dissolution Enhancement of Ziprasidone by Solid Dispersion Technique
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| Author:
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UPLOADED BY-ADMIN, JANARDHAN JUTURI, SRINIVAS REDDY DEVIREDDY, VASAVI PACHIKA
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| Abstract:
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The solubility behavior of drug is one of most challenging aspects in the formulation development. Enhanced dissolution of
drugs can help in improved bioavailability of the drug product. The objective of this work is to improve the solubility and
dissolution rate of poorly water soluble drug ziprasidone (antipsychotic agent) by solid dispersion method. Solid dispersions
of ziprasidone were prepared by fusion method using different carriers (Vit E TPGS, Gelucire 44/14 and 50/13) in different
ratios (1:0.1, 1: 0.2 and 1:0.3; Drug:Carrier) were used. The solubility was increased with increase in respective carrier
concentration. All solid dispersions have shown high dissolution rates as compared to pure ziprasidone. Ziprasidone with
Gelucire 44/14 at 1:0.3 ratio has significant improvement (four fold) in dissolution after 20 min than other carriers. In ageing
studies there was no significant difference was observed. FT-IR spectroscopy, differential scanning calorimetry studies
revealed that there was no significant interaction was occured between drug & carrier. From XRD studies the conversion of
crystalline form to amorphous form was observed.
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| Keyword:
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Ziprasidone, Vit E TPGS, Gelucire 44/14, 50/13, Fusion Method, Solid Dispersion.
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| DOI:
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