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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
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0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Development and Validation of RP-HPLC Method for Estimation of Etoposide in Liposomes

Author: A.R.FUGATE, S.N.NAGOBA, S.R.HYAM
Abstract: The incorporation of the medicine into a liposomal formulation aided in the achievement of targeted drug delivery. Various analytical techniques were used by the researcher to determine the amount of drug entrapped in the liposome. The goal of this study was to create an RP-HPLC method for estimating etoposide concentration in liposomes. As a mobile phase, methanol and water at pH 3.5 were used to create the process. The detection was carried out at a wavelength of 283 nm. It was discovered that the retention time was 2.491 minutes. The use of a short column with an id of 100 x 4.6 mm and a particle size of 2.5 m helps to shorten analysis time. The lower flow rate and longer retention period result in a well-resolved peak. The linearity, accuracy, precision, robustness, LOD, and LOQ properties of this approach were all validated. At 80, 100, and 120 percent, the percent recovery was determined to be 100.88, 99.59, and 101.58, respectively. 0.2215 g/ml and 0.6712 g/ml were found to be the LOD and LOQ, respectively. The validation results and statistical data revealed that the procedure is straightforward, cost-effective, repeatable, and appropriate for active ingredient and dosage form quality analysis.
Keyword: Etoposide, Liposomes, Method development, RP- HPLC, Validation
DOI: https://doi.org/10.31838/ijpr/2020.12.04.674
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