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Dithiocarbamate Substituted Pyridine Derivatives: Insilico Design, Synthesis, Biological Activity And Docking Study On Tubulin Receptor As Anticancer Agents
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| Author:
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ASHMA MD, MUNI SIREESHA S, ANUSHA KOTHA, JYOTI VEMURI, MUZAFFAR-UR-REHMAN MD, SARITHA JYOSTNA T
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| Abstract:
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An efficient protocol for highly chemoselective introduction of dithiocarbamate (1a) group to amine position of 4-(Aminomethyl) pyridine (1b) with alkyl/aryl halides were designed and synthesized in moderate yields to excellent yield at room temperature. Based on this methodology, seven novel 4-(Aminomethyl) pyridine-dithiocarbamate (1c) compounds were prepared with different substituent’s, also molecular properties prediction was performed to carry out the drug likeness properties, evaluated for antioxidant, anti-mitotic and tubulin protein inhibitory activities followed by docking studies to determine binding pattern to target enzyme for the synthesized compounds. All of the synthesized compounds were identified in terms of IR,1HNMR and Mass spectroscopy.
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| Keyword:
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4-(Aminomethyl) pyridine; Dithiocarbamate; Docking; Antioxidant Activity; Anti-mitotic Activity; Spectroscopy.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.118
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| Download:
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