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Oral Pulsatile Drug Delivery System- A Review
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| Author:
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SYED GOUSE FIROZ, R.KOTHAI, B.ARUL
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| Abstract:
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Pulsatile drug delivery system refers generally to the release by a burst of one portion of the overall payload, followed by a low or no release (lag phase) period in a predefined temporal pattern. They deliver the drugs in the right place at the correct time, in the right amount, which is more beneficial than conventional dosages and enhances patient compliance. Oral pulsatile drug release, in particular, refers to the burst delivery of drugs from the time of oral administration in a predetermined pattern. These systems are designed according to the body's circadian rhythm and the drug can quickly and fully be released after a lag period. These products adhere to the sigmoid release profile, which is defined by a time period. These systems are beneficial for drugs with chronopharmacological behavior, where the dosage is necessary, and for drugs with first-pass effects. This review covers the anatomy and physiology of colon-specific drug delivery methods developed for pulsatile delivery. Including asthma, peptic ulcers, cardiovascular conditions, arthritis, and attention deficit syndrome in children, and hypercholesterolemia, diseases with promising PDDS. Pulsatile drug delivery systems have the potential to bring new developments in the therapy of many diseases.
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| Keyword:
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Pulsatile; Colon-Specific; Factors; Polymers.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.669
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| Download:
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