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Evaluation of the Anti-Snake Venom Activity of Flavonoids from the Root Bark Extract of Parinari Curatellifolia in Mice
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| Author:
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UPLOADED BY-ADMIN, SIMEON OMALE, ASA AUTA, KENNEDY I. AMAGON, MRIOSE V. IGHAGBON
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| Abstract:
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Snake bites constitute a major public health problem worldwide. This research was carried out to evaluate the flavonoids
isolate of the root bark extract of Parinari curatellifolia for anti-snake venom activity. Flavonoids were isolated from the
root bark of Parinari curatellifolia by fractionation and the LD50 of the flavonoid extract was determined. Groups of 5 mice
each were pre-treated with the minimum lethal dose of venom (2.25 mg/kg) before the administration of graded doses of the
flavonoid extract of the root bark of Parinari curatellifolia. The results revealed that the LD50 of the Flavonoid fraction of
the P. curatellifolia was 948mg/kg. The flavonoid extract of the root bark of P. curatellifolia (at a dose of 237 mg/kg) was
found to offer significant (P < 0.05) protection against Echis carinatus venom at 10 minutes and 30 minutes after
pretreatment with the venom. The extract (237 mg/kg) did not show significant anti-snake venom activity at 60 minutes after
pretreatment with the venom. This study therefore demonstrated that flavonoids isolated from the root bark of Parinari
curatellifolia possessed anti-snake venom activity and can serve as an important source of a lead compound for the synthesis
and production of anti-snake venom.
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| Keyword:
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Anti-snake venom activity, flavonoids, Parinari curatellifolia.
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| EOI:
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| DOI:
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