|
Formulation and Characterisation of Meloxicam Loaded Nanosponges
|
|
| Author:
|
, BANTU SAM PRANAY CHARAN, DODDABOINA TARUN, SANIA EQRA, WANIYA SULTANA, KANAKAM VIJAYABHASKAR
|
| Abstract:
|
Objective: To design a controlled topical delivery system of Meloxicam (MX) in order to enhance skin permeation and treatment efficacy. Nanosponges were selected as a novel carrier for this purpose.
Methods: Nanosponges were formulated via the emulsion solvent evaporation method using ethyl cellulose (polymer) and polyvinyl alcohol (surfactant). Nanosponge dispersions were characterized for colloidal properties, entrapment efficiency and in vitro release study. The nanosponge formulation (LS1) was then incorporated into carboxymethyl cellulose sodium hydrogels and evaluated for pH, viscosity and in vitro drug release. Skin irritation was evaluated, and anti-inflammatory activity was assessed via rat hind paw edema method.
Results: Nanosponges were in the nano-sized range and attained a uniform round shape with a spongy structure. LS1exhibited the highest MX release after 6 h, so it was incorporated as hydrogel. Formulated hydrogels showed acceptable physicochemical parameters (pH, drug content and rheological properties). Skin irritation testing proved MX-loaded nanosponge hydrogel formulation (G1) to be non-irritant. In vivo study revealed an enhanced anti-inflammatory activity of G1 for 6 h (p<0.001).
Conclusion: The developed nanosponge hydrogel is an efficient nanocarrier for improved and controlled topical delivery of MX.
|
| Keyword:
|
Ethylcellulose, Meloxicam, Nanosponge, Topical delivery, Anti-inflammatory activity
|
| EOI:
|
-
|
| DOI:
|
https://doi.org/10.31838/ijpr/2021.13.03.150
|
| Download:
|
Request For Article
|
|
|