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Formulation and Evaluation of Lurasidone Hydrochloride NLC
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| Author:
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DR. N. DORA BABU
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| Abstract:
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Objective: The present study was an attempt to systemically deliver the most desirable schizophrenia drug, Lurasidone hydrochloride (LRS) via the intranasal route using nanostructured lipid carrier (NLC) approach.Methods: The desired LRS loaded NLCs were developed using central composite statistical design and the developed formulation was monitored for improving LRS bioavailability and their brain targeting efficacy.Results: Pharmacokinetic studies revealed a 10 fold increase (LRS blood-brain ratio) for NLCs administered through nasal route (in comparison to intravenous route). Similarly, the concentration of LRS (in the brain) delivered via nasal route exhibits 4 fold increment at all-time points.Conclusion: Therefore, the obtained results suggest a potential nose to brain transport of loaded LRS by effective bypassing of the Blood-Brain Barrier (BBB).
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| Keyword:
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Lurasidone hydrochloride, Nanostructured lipid carriers, Blood/Brain barrier, Intranasal delivery
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.137
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| Download:
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Request For Article
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