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Anti-Cancer and Antioxidant Activities of Ethanolic Exctract of Erythrina Senegalensis D.C. Bark
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| Author:
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, LAVKUSH TIWARI, DR.P. POLI REDDY, DR. SANTHOSH TIWARI, AISHWARYA KULKARNI
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| Abstract:
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Antioxidant and cytotoxic activity of ethanol bark extract was evaluated in the present study. HT-29 (Human, colorectal cancer), HeLa (Human, Epithelial cervical cancer) and C2C12 (Mouse, Muscle cell line) cell culture were exposed to various concentrations of extracts ranging from 7.8 µg/ml to 1000 µg/ml. The cytotoxicity study was carried out with MTT assay and free radical scavenging activity was evaluated using DPPH assay with ascDr.P.Polireddyorbic acid as standard. The results obtained in the present study reveals a potential cytotoxic activity especially against the MCF-7 cells where the IC50 amounts to 32.4µg/ml. The results were in correlation with the presence of antioxidant activity of the extract, where 94.45% scavenging of free radicals was observed with the presence of flavonoids, polyphenols and anthocyanins in the extracts. To conclude the ethanol bark extract imparts a target specific cytotoxicity with reference to HT-29,HeLa C2C12 cell lines and there is positive correlation was found to exist between the presence of antioxidant compounds and cytotoxicity against cancer cells.
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| Keyword:
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Ethanol bark, Erythrina Senegalensis
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.021
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| Download:
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Request For Article
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