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Study Of Teratogenic Effects Of Chinese Spinach Extract (Amaranthus Tricolor L) In Wistar Rat
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| Author:
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DEWI DAMAYANTI ABDUL KARIM , SITI ROHANI, PSIARI KUSUMA WARDANI, RAFI NUR FAIZI AKBAR, REDI ARIF MUZANI, VEVI INDRIANI, SALMA ADILA, NUR AMINUDIN
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| Abstract:
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Environmental factors such as the use of drugs that are teratogenic account for 16% of cases of congenital malformations. It has led people to use herbal plants in overcoming diseases experienced during the pregnancy process. Many plants have been used as traditional medicine, one of which is Chinese spinach leaves (Amaranthus tricolor L.). It has been widely used to treat dysentery, fever, and as an alternative to increasing blood flow. The purpose of this study was to determine the teratogenic effect of Chinese spinach leaves extract which was tested in vivo. The ethanol extract of these leaves is divided into three different doses, namely 50, 400, and 1000 mg given orally on the 6th to 15th day of pregnancy. On the 19th day, the female rats were dissected and the fetus was observed. The observations were made by observing abnormalities in the number of skeletons and organs in the fetus from the test and control groups and by observing the fetal body weight, the number of fetuses, and the amount of fetal resorption. There was no statistically significant difference between these three parameters in the test group (p> 0.05). The administration of Chinese spinach leaves extract at all test doses did not show any abnormalities in the fetal organs and did not cause abnormalities in the skeleton, so it could be concluded that Chinese spinach leaves extract did not cause teratogenicity.
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| Keyword:
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Chinese spinach, Amaranthus tricolor, Teratogenic.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2020.12.04.666
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