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INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

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IJPR included in UGC-Approved List of Journals - Ref. No. is SL. No. 4812 & J. No. 63703

Published by : Advanced Scientific Research
ISSN
0975-2366
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IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

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Anti-Snake Venom Activity of Strychnos Spinosa

Author: UPLOADED BY-ADMIN, ASA AUTA, SIMEON OMALE, JOHN ADAKOLE
Abstract: This research was aimed at investigating the anti-snake venom activity of Strychnos spinosa in order to confirm their local use. Groups of 5 mice each were pre-treated with the minimum lethal dose of Echis carinatus venom (2.13 mg/kg) for 10 minutes before administration of aqueous extract of the stembark of S spinosa. The results revealed that the LD50 of the aqueous stem-bark extract of S. spinosa was 2154.1 mg/kg. The extract exhibited a significant (p < 0.05) dose dependent anti-snake venom activity at doses of 500 mg/kg and 700 mg/kg.This study therefore confirm the local use of the plant in the treatment of snake bites.
Keyword: anti-snake venom activity, Strychnos spinosa.
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