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Distribution of Human Cystic Echinococcosis and Genotypes of Hydatid Cyst And Adult Worm of Echinococcus granulosus In Iran: A Systematic Review and Meta-Analysis
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| Author:
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SEYEDMOUSA MOTAVALLIHAGHI, MAHDI FAKHAR, MANOOCHEHR KARAMI, NASTARAN BARATI, PEGAH AMERI, KHADIJEH RAHMATI, MOHAMMAD FALLAH
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| Abstract:
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Introduction:Human Cystic Echinococcosis is one of the most important zoonotic diseases that is caused by the larva stage of Echinococcus granulosus sensu lato. Cystic Echinococcosis (CE) has been reported from more than 100 countries around the world. This study was performed to investigate the relationship between genotypes of human CE and adult worms in definitive hosts with reference to the prevalence of human CE in Iran.
Materials and Methods: To search for articles, databases of PubMed, Web of Science, Scopus, Med Library, Google Scholar, Iran Doc, Magiran, and SID were used. Also STROBE checklist was used to evaluate the article quality. Also assessment of inconsistency and quantity was done by chi-square and Sig 5% and I2 tests by STATA software. As well as Publication bias was assessed by using Begg’s and Egger’s tests.
Results: Investigation of genotypes showed G1, G3, and G6 in human CE and G1, G3, G6 and G7 in animal CE as intermediate host and G1, G2, G3 in adult form of Echinococcus in definitive host in Iran. Also for determination of human CE prevalence rate from Out of 3631 articles, 31 articles were included in this study. The prevalence rate of human CE was estimated 5%, as 60% positive cases in rural areas and 40% in urban was observed. The highest prevalence was seen in Khuzestan and Fars provinces with 12% and 7% respectively, also, most of the age groups involved were 20 to 40 years old (42%).
Conclusion: The results of this study indicate that a relatively high prevalence of human CE in Iran. Also, the study of genotypes in the intermediate host and final host indicates the dominant genotypes of G1, G3 and G6 in the intermediate hosts and G1, G2 and G3 in the definitive host.
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| Keyword:
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Echinococcosis, Echinococcus granulosus, Genotype,
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.788
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