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The effect of multiple intravitreal bevacizumab injection on the human corneal endothelial cells
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| Author:
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AKBAR DERAKHSHAN, MOHAMMAD SHIRVANI, ALIREZA ESLAMPOUR, MOHAMMADREZA ZARE, FARZAD NASERI , SHAHRAM BAMDAD
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| Abstract:
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Objectives: Vascular endothelial growth factor (VEGF) role in cell viability, presence of VEGF receptors on corneal endothelial cells and Bevacizumab in anterior chamber after intravitreal Bevacizumab (IVB) injection promotes the question of, is IVB injection toxic for corneal endothelial cells?
Materials and Methods: 40 patients who had undergo intravitreal injection monthly for 3 times were enrolled in this study. Once before the first and again a month after the third injection, specular microscopy was performed for cases and controls and compared with each other.
Results: Cell density , average cell size, standard deviation of cell size, coefficient of variation and central corneal thickness showed no significant change before and one month after the third IVB injection (p-values were 0.058, 0.077, 0.884, 0.241 and 0.202 respectively).
Conclusion: IVB injection has no adverse effect on human corneal endothelial cells.
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| Keyword:
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Anti VEGF, Bevacizumab, Corneal endothelial cells, Specular microscopy, Toxicity
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.766
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| Download:
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Request For Article
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