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The Efficacy of Short-term parentral chelator therapy in reduction of Blood Lead Level in lead intoxication related to opium addiction
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| Author:
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ABBAS AGHABIKLOOEI, SHAHROKH ALIZADEH, MARYAM AMERI
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| Abstract:
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Aim: The effects of parenteral chelating drug for treatment of lead poisoning in reduction of blood lead levels are a challengeable subject in comparison to oral forms. The purpose of this study is to gain deeper insights into the efficacy of parenteral chelating therapy in reduction of patients' blood lead level.
Method: In a cross-sectional study, 52 hospitalized symptomatic lead intoxicated patients were included..The clinical improvement and blood lead level before and after a short-course (3 days) intravenous chelator therapy was evaluated. Finally, the efficacy of mono and dual chelator therapy was compared.
Results: 32 of 52 cases (61.5%) had acute lead toxicity and were symptomatic few weeks to a few months after starting use of opium and 20 cases (%38.5) were chronic user of opium (addicted) and had chronic toxicity. The mean daily dose of oral opium was 3.2 gm (min:1, max:7, SD: 1.7) and the mean duration of opium use was 10 years (min: 6 month, max: 40 yrs, SD:9.1). The mean level of lead in blood before and after a short course parenteral chelating therapy was 114.7 and 56.4 mcg/dl, respectively.
Conclusion: This study showed that a single short term (3 days) parentral chelator therapy has a high efficiency on lowering the blood lead level and clinical improvement. The mean BLL will be diminished at mean of 49 percent after therapy (P value <0.001).
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| Keyword:
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Chelator, Lead, Poisoning, Opium, Intoxication, Addiction
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.763
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| Download:
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