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Self-Emulsifying Drug Delivery Systems: A Review
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| Author:
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, M.SARITHA , D.REVATHI, P.V.KAMALA KUMARI, Y.SRINIVASA RAO
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| Abstract:
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Self emulsifying drug delivery systems (SMEDDS) are vital methods to increase bioavailability of poorly soluble drugs by increasing solubility. As oral route is most preferred route of administration due to its painless application and the major problem faced by this route includes decreased bioavailability which lead to importance of evaluation of Self emulsifying drug delivery systems. Self micro emulsifying drug delivery systems especially preferred primarily because these are physically stable , easy to manufacture, can be filled in soft gelatin capsules and then will generate a drug containing micro emulsion with a large surface area upon dispersion in the gastro intestinal tract. Various components like surfactants, lipids, co-surfactants used to formulate self micro emulsifying formulations (droplet size <100nm) which contribute to overall improvement in oral bioavailability via promoting the lymphatic transport, there by hepatic 1st pass metabolism suppressed. The present paper provides information on formulation, physiochemical & bio-pharmaceutical aspects of SMEDDS along with factors affecting & evaluation of SMEDDS.
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| Keyword:
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SMEDDS, Bioavailability, Surfactants, Co-Surfactant.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.096
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| Download:
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