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Anti Diabetic Activity Of Solanum Seaforthianum In Streptozotocin & Nicotinamide Induced Diabetes Animal Model
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| Author:
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V S S S GUPTA ATYAM, NADENDLA RAMA RAO
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| Abstract:
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Diabetes mellitus is a metabolic disorder characterized by hyperglycemic condition along with impaired metabolic functions. There are many allopathic drugs are available to manage diabetes such as Glibenclamide, Metformin & Gleptines etc. but associated with side effects on long term usage and tolerance will be developed where we have to treat with multiple drugs. According to our ancient system of ayurveda there were many ancient medicinal plants available to manage diabetes which are absolutely free from side effects with the same efficacy as that of allopathic drugs. All these factors provoked me to initiate the present study of antidiabetic activity of Solanum seaforthianum in Streptozotocin & Nicotinamide induced diabetes animal model. In this study the diabetes was successfully induced with the help of Streptozotocin at a dose of 50 mg/kg body weight followed by Nicotinamide 120 mg/kg body weight and the animals which are possessing the glucose levels more than 200 mg/dl after 48 hours were included in the study. Then these diabetes induced animals were treated with Methanolic & chloroform extracts of Soalnum seaforthianum for 21 days which significantly reduced the elevated blood glucose levels and reversed other altered parameters of Cholesterol, Triglycerides, HDL, LDL, Urea, Creatinine, Insulin, SGOT, SGPT and Total Protein. Among the two extracts of Solanum seaforthianum Chloroform extract has shown comparatively significant anti diabetic activity in Streptozotocin and Nicotinamide induced diabetes in animal model.
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| Keyword:
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Solanum seaforthianum, Diabetes, Alloxan, Animal model.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.082
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| Download:
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