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Formulation, in-vitro evaluation and comparative study of diclofenac potassium loaded fast dissolving tablet using natural and synthetic superdisintegrants
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| Author:
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CHHITIJ THAPA, NILU KUMARI RAUNIYAR, ANITA YADAV, PRADYUMNA CHAUDHARI
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| Abstract:
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The study aims to extract and characterize starch and mucilage from Jackfruit seeds, Banana powder, Hibiscus leaves, Fenugreek seed, Mango peel, and Lepidium sativum and using these dry extracts as a natural superdisintegrant in the formulation of fast dissolving Tablets and comparing disintegration time with a commercially available synthetic superdisintegrant, Sodium Starch Glycolate. Various phytochemical test concludes the presence of polysaccharides in the extracts of natural superdisintegrants while no indications of the presence of alkaloids, glycosides, proteins, saponins, and other phenolic compounds were observed. Thirteen different formulations of diclofenac potassium loaded FDTs were prepared by the direct compression method and were subjected for both pre-compression and post-compression studies. Flow properties depicted the formulations to be within the considerable range indicating a good flow of powders while post-compression studies including weight variation, thickness, hardness, and friability of different formulations were within the acceptable limit.
A drug-excipient compatibility study was conducted using the FTIR spectrophotometer indicating no interaction between the drug and excipient. In vitro drug disintegration studies suggests minimum disintegration time in F4 with 19 seconds and maximum in F6 with 29 seconds. In vitro drug release also suggests a similar result with maximum drug release in F4 with 93.42±8.79 % and minimum in F6 with 86.42±8.36 %. Percentage drug release from the fast disintegrating Tablets formulations was observed to be significant (*P<0.05) when compared with the marketed product of Diclofenac potassium oral Tablets in acidic medium. The data were analyzed by Tukey’s post hoc multiple compression test.
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| Keyword:
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Fast dissolving Tablets, Diclofenac potassium, Disintegration time, Natural and synthetic super disintegrants, Direct compression method.
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.106
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| Download:
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