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Formulation and Evaluation of Solid Dispersion of Tinidazol by using Solvent Evaporation Method
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| Author:
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AMANDEEP SINGH, MAYANK THAKUR, PALLAVI TIWARI, RAJNEESH KUMAR
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| Abstract:
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Background: The aim of this study was to prepare and characterize solid dispersions of water insoluble antiprotozoal agent Tinidazole.
Method: The solid dispersion was prepared with various water soluble polymers such as Polyethylene glycol 4000, Polyethylene glycol 6000 and polyvinyl pyrrolidone in different ratio for enhancing the dissolution rate of the drug. The solid dispersions were prepared by solvent evaporation method at 1:1, 1:2 and 1:4 drugs to polymer ratios. Scanning electron microscopy, Infrared spectroscopic and differential scanning calorimetry were used to examine the physical state of the drug. Furthermore, the solubility and the dissolution rate of the drug in its different systems were studied.
Results: Differential scanning calorimetry thermograms showed the significant change in melting peak of the tinidazole, when prepared as solid dispersion suggesting the change in crystallinity of tinidazole. The highest ratio of the polymer (1:4) enhanced the drug solubility about 4-5 times in case of solid dispersion of tinidazole– Polyethylene glycol 6000 then other formulations. An increased dissolution rate of tinidazole at pH 1.2 and 7.4 was observed when the drug was dispersed in these carriers in form of physical mixtures or solid dispersion. Tinidazole released faster from the solid dispersion than from the pure crystalline drug or the Physical mixture.
Conclusion:The dissolution rate of Tinidazole from its Physical mixture or solid dispersion increased with an increasing amount of polymer.
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| Keyword:
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Solid dispersion, Tinidazole, Polyethylene glycol -6000, PEG-4000, Solubility, Dissolution rate
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| EOI:
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.104
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| Download:
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