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Extracts of Erythrina variegata reduce Triton induced Hyperlipidemia in rats
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| Author:
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UPLOADED BY-ADMIN, BIRADAR S S, PATIL P.A
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| Abstract:
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Lipid metabolism normally maintains balance between lipid synthesis and its degradation and when it is upset it leads to
hyperlipidemia, such as hypertriglyceridemia and hypercholesterolemia. Hyperlipidemia progresses to bring changes mainly
in the vascular tissue leading to atherosclerosis which in turn can cause hypertension and there by other organ diseases like
myocardial infarction, stroke etc. In the present study the extracts of barks of Erythrina variegata were tested for their
hypolipidemic activity on triton induced hyperlipidemia in rats. The alcoholic extract of Erythrina variegata showed the
significant reduction in total cholesterol and Low-Density Lipoprotein (p < 0.001). There was significant rise in High -
Density Lipoprotein level also, the Erythrina variegata aqueous extract 500 mg/kg showed decrease level of Low-Density
Lipoprotein (p<0.01) and petroleum ether extract 500 mg/kg showed significant rise in High -Density Lipoprotein ( p < 0.01
). This study showed that extracts of Erythrina variegata were effective against triton induced hyperlipidemia in rats.
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| Keyword:
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Erythrina variegata, triton, dyslipidemia
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| EOI:
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| DOI:
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