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A comprehensive review of floating microspheres
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| Author:
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ABDUL KAREEM S, AKILADEVI D, JEEVARAJ S
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| Abstract:
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Oral controlled release systems are designed to release drugs in a controlled manner in the body with precision
to improve effectiveness, reduce side effects, and maximize medication bioavailability. The gastric contents are
likely to keep floating drug delivery systems (FDDSs) buoyant for a long time. Hollow microspheres, granules,
powders, salts, capsules, pills, and laminated films are among the various buoyant preparations. Along with their
wide applicability in drug distribution to the stomach, floating microspheres are gaining prominence. Noneffervescent, gastro-retentive floating microspheres (Hollow Microspheres) In the strictest sense, hollow
microspheres are spherical empty particles without a nucleus, free-flowing powders consisting of proteins or
plastic polymers with a size spectrum of 1-1000 micrometres. Low-density structures with enough buoyancy to
float over gastric contents and sit in the stomach for a prolonged period of time are known as gastro-retentive
floating microspheres. Since the drug is released at a constant rate, it increases gastric stability and decreases
variance in plasma drug concentration. Floating microspheres can increase the therapeutic efficacy of short halflife medications by lowering dosing frequency, which improves patient compliance. Enhanced absorption of drugs
that only dissolve in the stomach, and increased gastric retention time due to buoyancy. Solvent diffusion and
evaporation processes are used to build the hollow inner structure of floating microspheres.
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| Keyword:
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Floating drug delivery systems, Gastro-retentive floating microspheres, Ionotropic Gelation Method, Gastric retention, hollow microspheres
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.072
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| Download:
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