*Five Years Citation in Google scholar (2016 - 2020) is. 1451*   *    IJPR IS INDEXED IN ELSEVIER EMBASE & EBSCO *       

logo

INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH

A Step Towards Excellence
Published by : Advanced Scientific Research
ISSN
0975-2366
Current Issue
Article In Press
No Data found.
ADOBE READER

(Require Adobe Acrobat Reader to open, If you don't have Adobe Acrobat Reader)

Index Page 1
Click here to Download
IJPR 9[3] July - September 2017 Special Issue

July - September 9[3] 2017

Click to download
 

Article Detail

Label
Label
Skeletal Muscle Atrophy; A review on pathogenesis and biomarkers

Author: DESAI SNEHA, KRISHNA K L, SEEMA MEHDI, AYACHIT SHREYAS, SWERNA E
Abstract: Skeletal muscle atrophy is a clinical condition which occurs due to various preliminary factors including the food, blood sugar levels, steroidal medications, etc. Muscle is a profuse tissue which occupies around 40% of the body weight. In the present review we have concise the information which might prove to be useful in understanding the pathology of muscle atrophy in the individual with co-morbid conditions. The mechanisms like autophagy, mitochondrial dysfunction, ubiquitin protease system, Akt/PI3K pathway, oxidative stress, lipid metabolism and deregulated calcium homeostasis pathways involved in skeletal muscle loss are discussed. We also reviewed the available therapeutics to treat muscle atrophy and biomarkers that need to be further researched on to understand the disease condition. Targeting the loss of muscle fibers can reduce high risk of mortality in majority of deadly diseases like cancer, cachexia, aging and related comorbidities. Further detailed research needs to be done to elucidate the mechanism and drug targets for muscle atrophy. There is lot of scope for development of novel therapeutics for muscle atrophy commonly seen in many disease conditions.
Keyword: Muscle, diabetes, biomarkers, therapeutics, physiology, atrophy
DOI: https://doi.org/10.31838/ijpr/2021.13.02.142
Download: Request For Article
 




ONLINE SUBMISSION
USER LOGIN


Username
Password
Login | Register
News & Events
SCImago Journal & Country Rank

Terms and Conditions
Disclaimer
Refund Policy
Instrucations for Subscribers
Privacy Policy

Copyrights Form

0.12
2018CiteScore
 
8th percentile
Powered by  Scopus
Google Scholar

hit counters free