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CNS Targeted Liposomal Delivery System via Nasal Fossae for Alzheimer’s Disease: A Review
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| Author:
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MS.SHRUTIKA SHARMA, MR.YASH DHARIWAL, MR.SAGAR PANWAR, MR.DEBAPRASAD GHOSH, DR.ASHU MITTAL
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| Abstract:
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The neurodegenerative disorder is a blanket term for slow yet progressive deterioration of the neurons within the Central Nervous System. Alzheimer’s disease is affiliated with a progressive dementia and impaired motor functions and is clinically categorized into seven stages. Advantages of the nasal delivery over the conventional methods of delivery include organ specificity, bypassing the first pass metabolism, painless and easy self-administration, as well as reduction of undesirable side effects. Some of the recent breakthroughs using liposomes include modifications in functional ligands, use of cationic vehicles and stealth liposomes to enhance the penetrability and broaden the duration of action. Over the years, scientists have efficiently explored the use of donepezil, galantamine, h102 peptide (beta- breaker), rivastigmine and curcumin encapsulated liposomes which have been proposed to improve symptoms of Alzheimer’s disease with limited toxicity, however the current work still pivots around preclinical developments. Hence, the purpose of this review article is to draw a contour on the recent advancements and possible future innovations related to drug delivery via nose.
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| Keyword:
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nasal fossae, dementia, first pass metabolism, stealth liposomes.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.03.030
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| Download:
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Request For Article
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