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Investigating the Influenza A Virus Proteins and Identifying the Role of Non-Structural Proteins of Ns1 And Ns2
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| Author:
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KEIVANLOU ZAHRA, SHOUSHTARI ABDUL HAMID
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| Abstract:
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Influenza is a contagious respiratory disease in human beings and animals caused by a virus of Orthomyxoviridae family. Influenza is one of the leading causes of death around the world. It affects a major part of human population every year. Also, many animal species are infected with influenza viruses, and some of these viruses can result in epidemic diseases in human species. The present study was conducted with the aim of investigating the influenza A virus proteins and identifying the role of the non-structural proteins of NS1 and NS2. The results of this study showed that the genome of these viruses consisted of 8 single-stranded RNAs with negative polarity. This eight-segment genome encoded 10 structural proteins, including M1, M2, NP, NA, HA, PA, PAx, -F PB1, PB1, PB2 and two non-structural proteins, including NS1 and NS2 / NEP. One of the crucial internal genes and proteins was NS1 (Non-structural gene) that prevented pre-mRNA splicing. As a result of this protein splicing, another protein called as NS2 / NEP (Nuclear Export Protein) was formed, which was responsible for transferring the RNP (Ribonuleaoprotein) produced from the nucleus to the cytoplasm. Recent studies have indicated that the viral NS1 protein (with more than 140 cellular proteins) is involved in the process of RNA production, apoptosis, and most importantly, it is associated with innate immunity. It also takes the cells to replicate the virus. Based on the results of the present study, NS1 plays a key role for any virus adaptation.
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| Keyword:
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Influenza A, Virus, Non-structural protein, Structural protein.
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| EOI:
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-
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| DOI:
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https://doi.org/10.31838/ijpr/2021.13.01.751
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| Download:
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